• 1
  • 2
  • 3
2025年5月21日 星期三
  • 网站首页
  • 期刊介绍
  • 编委会
    第八届编辑委员会
    历届编辑委员会
  • 审稿专家
    致谢2024年度为本刊审稿的各位专家!
    致谢2023年度为本刊审稿的各位专家!
    致谢2022年度为本刊审稿的各位专家!
    致谢2021年为本刊审稿的各位同行专家!
    致谢2020年为本刊审稿的各位同行专家!
    致谢2019年为本刊审稿的各位同行专家!
    致谢2018年为本刊审稿的各位同行专家!
    致谢2017年为本刊审稿的各位同行专家!
    致谢2016年为本刊审稿的各位同行专家!
    致谢2015年为本刊审稿的各位同行专家!
    致谢2014年为本刊审稿的各位同行专家!
    致谢2013年为本刊审稿的各位同行专家!
    致谢2012年为本刊审稿的各位同行专家!
    致谢2011年为本刊审稿的各位同行专家!
    致谢2010年为本刊审稿的各位同行专家!
  • 期刊订阅
  • 作者指南
    投稿须知
    写作指南
    联系我们
  • 出版规范
  • 开放获取
  • 论文自检
  • English
引用本文:牛东玲, 胡礼芳, 马 茜, 石 晶, 白明生.松萝酸活性作用机理及其物种资源研究概况[J].广西植物,2019,39(1):136-142.[点击复制]
NIU Dongling, HU Lifang, MA Qian, SHI Jing, BAI Mingsheng.Review on bioactivity mechanism and species resources of usnic acid[J].Guihaia,2019,39(1):136-142.[点击复制]
【打印本页】   【下载PDF全文】   【查看/发表评论】  【下载PDF阅读器】  【关闭】
←前一篇|后一篇→ 过刊浏览    高级检索
本文已被:浏览 6226次   下载 2662次 本文二维码信息
码上扫一扫!
分享到: 微信 更多
字体:加大+|默认|缩小-
松萝酸活性作用机理及其物种资源研究概况
牛东玲*, 胡礼芳, 马 茜, 石 晶, 白明生
宁夏大学 生命科学学院, 银川 750021
摘要:
松萝酸是地衣中分布最广泛、含量最丰富的地衣酸之一,因早期作为抗生素而闻名于世。近20年来,有关松萝酸在抗菌、抗病毒、抗肿瘤等方面的活性作用机理不断有新的突破。研究揭示松萝酸主要通过影响细菌生物膜的形成、抑制细菌及病毒RNA和DNA的合成从而达到抑制细菌和病毒的目的,通过诱导肿瘤细胞程序性凋亡及抑制肿瘤细胞DNA的合成等途径,达到杀死肿瘤细胞的效果,并且松萝酸还具有抑制肿瘤细胞迁移的能力。但与此同时,松萝酸作为减肥营养补充剂而引发肝细胞线粒体功能障碍,进而导致肝脏损伤的作用也日益受到了科学界的关注。为更好地把握松萝酸资源研究开发的方向,该文对近20年来松萝酸在抗菌、抗病毒、抗肿瘤等活性方面的作用机理及肝脏毒性方面的研究进行了归纳分析。截至目前,松萝酸在隶属于35个属的种里被报道有分布,其中大多数是枝状地衣,其次为叶状地衣,壳状地衣只有个别种里有。该文也对目前已报道的含有松萝酸的属种及有关影响松萝酸含量的环境因子的研究进行了全面的梳理,以期为富含松萝酸的优良种质资源的发掘和开展后续活性作用研究需要面对的松萝酸种质资源问题提供理论帮助
关键词:  抗肿瘤活性, 肝脏毒作用, 作用机理, 地衣, 松萝酸资源
DOI:10.11931/guihaia.gxzw201801035
分类号:Q945
文章编号:1000-3142(2019)01-0136-07
基金项目:国家自然科学基金(31660007, 31360040)[Supported by the National Natural Science Fundation of China(31660007,31360040)]。
Review on bioactivity mechanism and species resources of usnic acid
NIU Dongling*, HU Lifang, MA Qian, SHI Jing, BAI Mingsheng
College of Life Sciences, Ningxia University, Yinchuan 750021, China College of Life Sciences, Ningxia University, Yinchuan 750021, China
Abstract:
Usnic acid is one of the most widely distributed and the most abundant compounds in lichens, and is rather well known as the antibiotic in the early stage. Due to its availability and easily isolated from many lichen species, many aspects of biological activity have been discovered. In the past 20 years, research reports on the active mechanism of usnic acid in antibacterial, antiviral, anticancer and other aspects have been keeping up with new breakthroughs. Research revealed usnic acid had antibacterial and antiviral effects by inhibiting biofilm formation of bacteria and synthesis of RNA and DNA, and usnic acid could kill tumor cells by inducing programmed apoptosis and inhibiting synthesis of DNA of tumor cells. Furthermore, usnic acid had an ability of inhibiting tumor cell migration. But usnic acid as nutritional supplements for weight loss was found to trigger mitochondrial dysfunction in liver cells that results in liver damage, which has been paid more and more attention in the scientific community. In order to grasp the domestic and external research trends of usnic acid resources development, this paper focuses on a comprehensive analysis on antibacterial, antiviral, anticancer action mechanism and liver toxicity researches of usnic acid around the last two decades. To date, lots of lichen species subordinate to about 35 genera have been found to contain more or less usnic acid, most of these species with usnic acid are fruticose lichens, followed by folicose lichens, only very rare cruticose liches are found to contain usnic acid. Research reports on genera and species resources rich in usnic acid have been sorted out comprehensively, and environmental factors affecting the content of usnic acid have been also summarized in detail in order to provide a theoretical basis for the discovery of potential resources rich in usnic acid and for solving the raw material problem needed for further study of activity.
Key words:  anticancer activity, liver toxicity, active mechanism, lichen, usnic acid resources
桂ICP备15006611号-1
地址:广西桂林市雁山区雁山街85号 广西壮族自治区中国科学院广西植物研究所  《广西植物》编辑部,邮编:541006 电话:0773-3550074
E-mail:guihaia@vip.163.com(投稿系统);guihaia@126.com(稿件处理);guihaia@gxib.cn(业务联系)  网址:http://www.guihaia-journal.com
技术支持:北京勤云科技发展有限公司