柬埔寨柯拉斯那沉香的化学成分研究

夏录录<sup>1; 2</sup>; 李 薇<sup>2</sup>; 梅文莉<sup>2</sup>; 杨 理<sup>2</sup>; 蔡彩虹<sup>2</sup>; 姜 北<sup>1</sup>; 戴好富<sup>2*</sup>

引用本文:	夏录录, 李薇, 梅文莉, 杨理, 蔡彩虹, 姜北, 戴好富.柬埔寨柯拉斯那沉香的化学成分研究[J].广西植物,2019,39(4):540-547.[点击复制]
	XIA Lulu, LI Wei, MEI Wenli, YANG Li, CAI Caihong, JIANG Bei, DAI Haofu.Chemical constituents of agarwood originating from Aquilaria crassna in Cambodia[J].Guihaia,2019,39(4):540-547.[点击复制]

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柬埔寨柯拉斯那沉香的化学成分研究
夏录录^1,2, 李薇², 梅文莉², 杨理², 蔡彩虹², 姜北¹, 戴好富^2*
1. 大理大学药学与化学学院, 云南大理 671003;2. 中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101

摘要:

该文采用 ODS、硅胶、Sephadex LH-20 等柱色谱技术,对柬埔寨野生柯拉斯那沉香(Aquilaria crassna)进行了研究。结果表明:从柬埔寨柯拉斯那所产沉香的乙醇提取物中进行分离共得到了10个化合物,包括一对对映异构体(9a/9b)。经波谱解析分别鉴定为6-甲氧基-2- [2-(3-羟基-4-甲氧基苯)乙基]色酮(1)、6-甲氧基-2- [2-(3-甲氧基-4-羟基苯)乙基]色酮(2)、6,7-二甲氧基-2-(2-苯乙基)色酮(3)、6-羟基-2-(2-苯乙基)色酮(4)、6-羟基-2- [2-(4-甲氧基苯)乙基]色酮(5)、8-氯-6-羟基-2- [2-(3-羟基-4-甲氧基苯)乙基]色酮(6)、8-氯-6-羟基-2- [2-(4-甲氧基苯)乙基]色酮(7)、oxidoagarochromone B(8)、4'-demethoxyaqusisnenone D(9)。其中,化合物6、7和9均为首次从柯拉斯那沉香中分离得到。活性测试结果显示,化合物1和2对乙酰胆碱脂酶具有一定的抑制活性,化合物2对人慢性髓原白血病细胞K562具有较弱的抑制作用。

关键词: 柬埔寨, 沉香, 柯拉斯那, 化学成分, 乙酰胆碱脂酶抑制活性, 细胞毒活性

DOI：10.11931/guihaia.gxzw201808023

分类号:Q946.91, R285.5

文章编号:1000-3142(2019)04-0540-08

基金项目:海南省自然科学基金(创新研究团队项目)(2017CXTD020); 中国热带农业科学院院级创新团队项目(17CXTD-15, 17CXTD-30); 现代农业产业技术体系建设专项项目(CARS-21)[Supported by Innovative Research Team Grant of the Natural Science Foundation of Hainan Province(2017CXTD020); Central Public-interest Scientific Institution Basal Research Fund for CATAS(17CXTD-15, 17CXTD-30); China Agriculture Research System(CARS-21)]。

Chemical constituents of agarwood originating from Aquilaria crassna in Cambodia

XIA Lulu^1,2, LI Wei², MEI Wenli², YANG Li², CAI Caihong², JIANG Bei¹, DAI Haofu^2*

1. Pharmacy and Chemistry College, Dali University, Dali 671003, Yunnan, China;2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Bio-technology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China 1. Pharmacy and Chemistry College, Dali University, Dali 671003, Yunnan, China; 2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Bio-technology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

Abstract:

Ten compounds, including one pair of enantiomers(9a/9b), were isolated from the ethanol extract of agarwood originating from Aquilaria crassna in Cambodia by comprehensive chromatographic techniques including ODS, silica gel and Sephadex LH-20. On the basis of spectroscopic data, they were identified as 6-methoxy-2- [2-(3-hydroxy-4-methoxyphenyl)ethyl] chromone(1), 6-methoxy-2- [2-(3-methoxy-4-hydroxyphenyl)ethyl] chromone(2), 6,7-dimethoxy-2-(2-phenylethyl)chromone(3), 6-hydroxy-2-(2-phenylethyl)chromone(4), 6-hydroxy-2- [2-(4-methoxyphenyl)ethyl ] chromone(5), 8-chloro-6-hydroxy-2- [2-(3-hydroxy-4-methoxyphenyl)ethyl]chromone(6), 8-chloro-6-hydroxy-2- [2-(4-methoxyphenyl)ethyl] chromone(7), oxidoagarochromone B(8), 4'-demethoxyaqusisnenone D(9). Compounds 6, 7 and 9 were isolated from agarwood of A. crassna for the first time. Among those, compounds 1 and 2 showed inhibitory activities against acetylcholinesterase. Compound 2 had weak inhibitory effect on K562 cell lines.

Key words: Cambodia, agarwood, Aquilaria crassna, chemical constituents, acetylcholinesterase inhibitory activity, cytotoxic activity