| 引用本文: | 李姝瑶, 李桂勤, 庞 闹, 王亚凤, 阳丙媛,
葛 利, 杨克迪, 黄永林, 刘章彬.红根草的化学成分及其抗氧化活性研究[J].广西植物,2026,46(8):1394-1404.[点击复制] |
| LI Shuyao, LI Guiqin, PANG Nao, WANG Yafeng, YANG Bingyuan,
GE Li, YANG Kedi, HUANG Yonglin, LIU Zhangbin.Chemical constituents from Salvia prionitis and their antioxidant activities[J].Guihaia,2026,46(8):1394-1404.[点击复制] |
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| 红根草的化学成分及其抗氧化活性研究 |
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李姝瑶1,2, 李桂勤2, 庞 闹1,2, 王亚凤2, 阳丙媛2,
葛 利1, 杨克迪1, 黄永林2, 刘章彬2*
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1. 广西大学 医学院, 南宁 530004;2. 广西壮族自治区
中国科学院 广西植物研究所, 广西植物功能
物质与资源持续利用重点实验室, 广西 桂林 541006
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| 摘要: |
| 为探究红根草(Salvia prionitis)的化学成分及其抗氧化活性,该研究采用MCI、硅胶、ODS、HW-40F及高效液相色谱(HPLC)对红根草乙酸乙酯部位进行分离纯化,并且综合运用波谱学方法(1D/2D-NMR、HR-MS、CD)及化学计算鉴定化合物结构,通过1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除法评价化合物的抗氧化能力。结果表明:(1)从红根草中分离得到17个化合物,分别鉴定为3-hydroxysalvinolone(1)、丹参酚酮(2)、salviadesertin J(3)、5α,11,12-trihydroxy-6-oxaabieta-8,11,13-trien-7-one(4)、桧醇(5)、perovskin C(6)、4-羟基红根草对醌(7)、prineoparaquinone(8)、miltiolactone(9)、2α,3α-dihydroxyursolic acid 28-O-β-D-glucopyranosyl ester(10)、19α-羟基积雪草酸(11)、齐墩果酸(12)、橙皮苷(13)、异槲皮苷(14)、芦丁(15)、山奈酚-3-O-β-D-葡萄糖苷(16)和山奈酚-3-O-芸香糖苷(17)。其中,化合物1为新化合物,化合物4、6、10、11、13和17为首次从鼠尾草属植物中分离得到,化合物3和9为首次从该植物中分离得到。(2)DPPH自由基清除测试结果表明,化合物14[IC50 =(0.009 2±0.000 06)mmol·L-1]和15[IC50=(0.013 2±0.000 06)mmol·L-1]的活性强于阳性对照[抗坏血酸,IC50 =(0.044 2±0.000 46)mmol·L-1]。该研究结果可为红根草抗氧化相关产品的开发提供理论依据。 |
| 关键词: 红根草, 化学成分, 分离鉴定, 萜类化合物, 抗氧化活性 |
| DOI：10.11931/guihaia.gxzw202511008 |
| 分类号:Q946 |
| 文章编号:1000-3142(2026)08-1394-11 |
| 基金项目:广西植物研究所基本科研业务费资助项目(桂植业25008); 广西植物功能物质与资源持续利用重点实验室主任基金(ZRJJ2024-1); 广西自然科学基金项目(20205GXNSFBA069156)。 |
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| Chemical constituents from Salvia prionitis and their antioxidant activities |
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LI Shuyao1,2, LI Guiqin2, PANG Nao1,2, WANG Yafeng2, YANG Bingyuan2,
GE Li1, YANG Kedi1, HUANG Yonglin2, LIU Zhangbin2*
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1. Medical College, Guangxi University, Nanning 530004, China;2. Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable
Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, Guangxi, China
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| Abstract: |
| To study the constituents from Salvia prionitis and their antioxidant activities. The ethyl acetate fraction of S. prionitis was separated and purified by a combination of column using MCI, silica gel, ODS, HW-40F, and high performance liquid chromatography(HPLC). The structures of obtained compounds were determined on the basis of spectroscopic data(1D-/2D-NMR, HR-MS, CD)and chemical calculations. The antioxidant capacities were evaluated using the1, 1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging assay. The results were as follows:(1)Seventeen compounds identified as 3-hydroxysalvinolone(1), salvinolone(2), salviadesertin J(3), 5α,11,12-trihydroxy-6-oxaabieta-8,11,13-trien-7-one(4), hinokiol(5), perovskin C(6), 4-hydroxysapriparaquinone(7), prineoparaquinone(8), miltiolactone(9), 2α,3α-dihydroxyursolic acid 28-O-β-D-glucopyranosyl ester(10), 19α-hydroxyasiatic acid(11), oleanolic acid(12), hesperidin(13), isoquercitrin(14), rutin(15), kaempferol-3-O-β-D-glucoside(16), and kaempferol-3-O-rutinoside(17). Compound 1 was identified as a new compound. The compounds 4, 6, 10, 11, 13, and 17 were the first time isolated from the genus Salvia plants, while compounds 3 and 9 were the first time obtained from S. prionitis.(2)The results of the DPPH free radical scavenging assay showed that compounds 14 [IC50=(0.009 2±0.000 06)mmol·L-1] and 15 [IC50=(0.013 2±0.000 06)mmol·L-1)exhibited stronger antioxidant activities than the positive control [ascorbic acid, IC50=(0.044 2±0.000 46)mmol·L-1]. This study provides a theoretical basis for developing novel derivatives from S. prionitis with enhanced antioxidant activity, guiding future product discovery efforts. |
| Key words: Salvia prionitis, chemical constituents, separation and identification, terpenoids, antioxidant activity |
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