类芒齿黄芪地下部分化学成分研究(英文)

Chemical constituents from underground part of Astragalus camptodontoides

关键词:  类芒齿黄芪, 地下部分, 化学成分, 分离与鉴定

Key words:   Astragalus camptodontoides, underground part, chemical constituents, isolation and identification

摘要:

为了解类芒齿黄芪(Astragalus camptodontoides)主要化学成分,从其地下部分甲醇提取物的乙酸乙酯部位分离出19个单体化合物,通过现代波谱分析及理化性质等手段分别鉴定为异补骨脂黄酮(1),4'-hydroxyisolonchocarpin(2),5-去氧山豆根黄酮(3),shinflavanone(4),khonklonginols H(5),4'-O-methylpreglabridin(6),3'-hydroxy-4'-O-methylglabridin(7),4'-O-methylglabridin(8),8-prenyl-phaseollinisoflavan(9),xambioona(10),光甘草酚(11),粗毛甘草素H(12),methylnissolin(13),邻苯二甲酸异丁酯(14),邻苯二甲酸丁酯异丁酯(15),β-谷甾醇(16),胡萝卜苷(17),齐墩果酸(18),(2S,3S,4R,9E)-1,3,4-trihydroxy-2- [(2'R)-2'- hydr-oxytetracosanoylamino]-9-octadecene(19)。化合物1～19均为首次从该植物中获得,化合物1～7为首次从黄芪属(Astragalus)植物中分离得到。

Abstract:

For understanding the chemical constituents of Astragalus camptodontoides, nineteen compounds were isolated from the ethyl acetate fraction of the methanol extract of underground part. By physical-chemical properties and spectroscopic date, their structures were identified as isobavachin(1), 4'-hydroxyisolonchocarpin(2), 5-deoxyeuchrenone(3), shinflavanone(4), khonklonginols H(5), 4'-O-methylpreglabridin(6), 3'-hydroxy-4'-O-methylglabridin(7), 4'-O-methylglabridin(8), 8-prenyl-phaseollinisoflavan(9), xambioona(10), glabrol(11), glyasperin H(12), methylnissolin(13), phthalic acid isodibutyl ester(14), butul isobutyl phthalate(15), β-sitosterol(16), daucosterol(17), oleanic acid(18), and(2S,3S,4R,9E)-1,3,4-trihydroxy-2- [(2'R)-2'-hydroxytetracosanoylamino]-9-octadecene(19). All compounds were isolated from this plant for the first time, including compounds 1-7 obtained from Astragalus genus for the first time.