L-阿拉伯糖对尿酸的调节作用

Effects of L-arabinose on modulating levels of uric acid in mouse

关键词:  L-阿拉伯糖, 尿酸, 黄嘌呤氧化酶, 氧嗪酸钾, 次黄嘌呤

Key words:  L-arabinose, uric acid, xanthine oxidase, oxonic acid potassium salt, hypoxanthine

摘要:

该文研究了L-阿拉伯糖对正常及高尿酸血症小鼠尿酸的调节作用。在正常小鼠、氧嗪酸钾和次黄嘌呤联合诱导的高尿酸血症小鼠以及氧嗪酸钾和尿酸联合诱导的高尿酸血症小鼠中,通过灌胃给予L-阿拉伯糖:收集尿液,测定尿酸排泄量; 取血,测定血清中尿酸、总胆固醇、甘油三酯、血糖、肌酐、尿素氮等常规生化指标; 处死小鼠后,取肝、肾、脾,称重,计算脏器指数; 取小肠与肝脏,匀浆后测定黄嘌呤氧化酶活性。结果表明:L-阿拉伯糖对正常小鼠,可以增加尿酸排泄,但不能降低血尿酸水平; 对氧嗪酸钾和次黄嘌呤联合诱导的高尿酸血症小鼠,对尿酸排泄没有影响,但能升高血尿酸水平; 对氧嗪酸钾和尿酸联合诱导的高尿酸血症小鼠,对尿酸排泄及血尿酸水平都没有影响。该研究结果表明L-阿拉伯糖对正常血尿酸水平没有影响,但能升高特定条件下高尿酸血症小鼠的血尿酸水平。

Abstract:

To study the effects of L-arabinose on modulating levels of uric acid in hyperuricemia and normal mice. L-arabinose were administrated to hyperuricemia mice and normal mice. Mice models with hyperuricemia were induced with oxonic acid potassium salt and hypoxanthine or with oxonic acid potassium salt and uric. We determinated levels of urate excreted. We also measured levels of uric acid, total cholesterol, triglyceride, glucose, creatinine, urea nitrogen in serum, xanthine oxidase activity in liver and small intestine, liver index, kindey index and spleen index. The results showed that L-arabinose could promote uric acid excretion, but had no effect on serum levels of uric acid in normal mice; could promote serum levels of uric acid, but had no effect on uric acid excretion in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine; had no effect on uric acid excretion and serum levels of uric acid in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine uric. This indicates that L-arabinose has no effect on normal serum levels of uric acid; but can promote serum levels of uric acid in mice models with hyperuricemia induced with oxonic acid potassium salt and hypoxanthine.