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鹊肾树树皮的化学成分和抗炎作用研究
陈自占1, 李俊1,2*, 吴强2, 杨瑞云2, 黎露清2, 李珊1,3, 黄纪国1,3
1.珍稀濒危动植物生态与环境保护教育部重点实验室, 广西师范大学 环境与资源学院, 广西 桂林 541004;2.药用资源化学与药物分子工程教育部重点实验室,广西 桂林 541004;3. 广西环境工程与保护评价重点实验室, 广西 桂林 541004
摘要:
通过药理实验确定了鹊肾树树皮的乙酸乙酯萃取物为抗炎活性部位,并利用色谱技术从该部位中分离得到了7个化合物,通过UV、IR、NMR、MS等现代谱学方法鉴定化合物的结构分别为:丁二酸(1)、6 乙基 5 羟基 2,7 二甲氧基 1,4 萘醌(2)、3β,20 二羟基 5β 孕甾烷(3)、5 羟基麦芽酚(4)、双[5 甲酰基糠基]醚(5)、5 羟甲基糠酸(6)、β 胡萝卜苷(7)。除β 胡萝卜苷,其余6个化合物均为首次从该植物中发现。
关键词:  鹊肾树树皮  抗炎  化学成分  分离鉴定
DOI:
分类号:R914
Fund project:
Chemical constituents and antiphlogistic activity of the bark of Streblus asper
CHEN ZiZhan1, LI Jun1,2*,Wu Qiang2, Yang RuiYun2, Li LuQing2, Li Shan1,3, Huang JiGuo1,3
1.Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education of China), School of Environment and Resource of Guangxi Normal University,Guilin 541004, China;2.Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China), Guilin 541004, China;3.3.The Guangxi Key Laboratory of Environment Engineering Protection and Assessment, Guilin 541004, China
Abstract:
The antiphlogistic part of the barks of Streblus asper was investigated through pharmacological experiments. Through the use of chromatographic technology,seven compounds were isolated from the antiphlogistic part of,and their structures were identified by spectroscopic analyses,especially NMR.They are:succinic acid(1),6 ethyl 5 hydroxy 2,7 dimethoxy 1,4 naphthoquinone(2),3β,20 dihydroxy 5β pregnanes(3),5 oxymalto1(4),bis (5 formyl furfuryl)ether(5),5 hydroxymethyl furoic acid(6)and β daucosterol(7). All compounds were isolated from this plant for the first time except for β daucosterol.
Key words:  bark of Streblus asper  antiphlogistic  chemical constituents  isolation identification
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