| 摘要: |
| 采用小鼠避暗行为学实验测定干花豆对老年痴呆小鼠记忆能力的影响,通过测定血液中的甘油三酯、总胆固醇及血液和大脑中的抗氧化指标来评价干花豆抗衰老作用。结果表明:干花豆各剂量组均能降低血脂水平,提高抗氧化能力,其中粗提物和正丁醇组有改善记忆力的作用,说明干花豆抗衰老的有效部位可能在正丁醇提取部位。 |
| 关键词: 老年性痴呆症小鼠 学习记忆能力 潜伏时间 超氧化物歧化酶 丙二醛 |
| DOI：10.3969/j.issn.1000-3142.2014.05.026 |
| 分类号:Q946; R285.5 |
| Fund project: |
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| Protective effects of fordia cauliflora hemsl on the D-galactose induced senile dementia model mice |
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YANG Zi-Ming, LIU Jin-Lei*, YAN Xiao-Jie, LI Dian-Peng
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Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin 541006, China
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| Abstract: |
| KM Alzheimier's disease mice models caused by D-galactose,the abilities of learning and memory of mice were investigated by avoid dark experiment in all animals,and antioxidant were used to study protective effects of fordia cauliflora hemsl on the D-galactose induced senile dementia model mice. Fordia cauliflora hemsl could increased antioxidant and decreased lipids,but the results suggested that fordia cauliflora hemsl and fordia cauliflora hemsl butanol extract might be beneficial to inproving the learning and memory behaviors in mice with Alzhemiers' disease induced by D-galactose. The results of pharmacological experiment results confirmed that the active part of fordia cauliflora hemsl butanol extract. |
| Key words: aging mice ability of learning and memory latency SOD MDA |
