红背山麻杆叶的化学成分研究(Ⅳ)—多酚类化合物(英文)

Chemical constituents from the leaves of Alchornea trewioides(4). Polyphenols

关键词:  红背山麻杆  化学成分  多酚  鞣花酸  提取与分离

Key words:  Alchornea trewioides  chemical constituents  polyphenols  ellagic acid  extraction and separation

摘要:

红背山麻杆(Alchornea trewioides)为山麻杆属植物,作为传统的中药被用来减轻疾病和身体不适,但它的药效物质基础尚未完全清楚。为了全面掌握红背山麻杆药效物质基础,采用80%丙酮对其新鲜叶进行提取,并利用MCI gel CHP 20P、Sephadex LH-20等色谱柱进行分离共得到9个化合物。这些化合物的结构经氢谱与碳谱比较分析鉴定为鞣花酸(1)、3-O-甲基没食子酸(2)、decarboxyellagic acid(3)、1-O-没食子酰基-β-D-葡萄糖(4)、1,6-二-O-没食子酰基-β-D-葡萄糖(5)、柯里拉京(6)、叶下珠鞣质D(7)、furosonin(8)、老鹳草素(9)。其中化合物2～9均为首次从该属植物中分离得到。

Abstract:

Alchornea trewioides, as atraditional Chinese medicine, was used to alleviate illness and discomfort in China, but the material basis of pharmacodynamic was unknown. In order to research for the material basis of pharmacodynamic from A. trewioides leaves, the fresh leaves of A. trewioides were extracted with 80% aqueous acetone and assigned by petroleum ether and water. The petroleum ether and water extracts were subjected to the column chromatography by MCI gel CHP 20P, Sephadex LH-20, and Toyopearl Butyl-650C, respectively, to yield nine polyphenols. Their structures were identified by means of ¹H NMR, ¹³C NMR, DEPT, and comparison with literature as: ellagic acid(1), 3-O-methylellagic acid(2), decarboxyellagic acid(3), 1-O-galloyl-β-D-glucose(4), 1,6-di-O-galloyl-β-D-glucose(5), corilagin(6), phyllanthusiin D(7), furosonin(8), and geraniin(9), respectively. Compounds 2-9 were obtained from A. trewioides for the first time.