| 摘要: |
| 穿心莲是我国重要的南药之一,其主要活性成分穿心莲内酯类成分具有清热解毒、抗菌消炎等功效,在抗HIV病毒、抗血栓、保肝等方面具有显著效果。由于其人工合成困难,通过栽培调控或育种方法增强穿心莲体内内酯类成分的生物合成对提升穿心莲药材质量具有重要意义。为给相关研究提供参考,该文综述了穿心莲内酯类成分积累与植物发育的关系,栽培措施和环境因子对穿心莲内酯类成分积累的影响,以及近十年来国内外在穿心莲内酯类成分的生物合成及其分子调控机制等方面取得的研究进展,并提出了未来在以增强穿心莲内酯类成分生物合成和提高穿心莲内酯类成分积累为目标的研究中需重点关注的3个方面:(1)深入解析穿心莲内酯的生物合成通路及关键基因的功能,从分子水平上阐明穿心莲内酯类成分积累的机制;(2)结合分子生物学方法和作物栽培学理论深入研究穿心莲生长发育与产量和质量形成的规律及相互关系;(3)揭示穿心莲内酯生物合成的信号调控网络。 |
| 关键词: 穿心莲, 环境因子, 穿心莲内酯, 生物合成, 植物激素 |
| DOI：10.11931/guihaia.gxzw202010034 |
| 分类号:Q943 |
| 文章编号:1000-3142(2021)10-1746-09 |
| Fund project:广西壮族自治区药用植物园基金(桂药基202003); 广西自然科学基金(2020GXNSFAA159025); 现代农业产业技术体系建设专项(CARS-21); 广西创新驱动科技发展项目(桂科AA18242040)[Supported by the Scientific Research Funding Project of Guangxi Botanical Garden of Medicinal Plants(202003); Guangxi Natural Science Foundation of China(2020GXNSFAA159025); China Agriculture Research System of MOF and MARA(CARS-21); Guangxi Innovation-Driven Development Project(AA18242040)]。 |
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| Advances in regulation studies on accumulation and biosynthesis of andrographolide components in Andrographis paniculata |
|
ZHONG Chu1,2, JIAN Shaofen1,2, CHEN Dongliang1,2, MIAO Jianhua1,2
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1. Guangxi Key Laboratory of Medicinal Resource Protection and Genetic Improvement, Guangxi Botanical Garden of
Medicinal Plants, Nanning 530023, China;2. Guangxi Engineering Research Centre of TCM Intelligent
Creation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China
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| Abstract: |
| Andrographis paniculata, known as ‘Chuanxinlian' in China, is an important southern medicine in China. Its main active ingredients, andrographolide components, has good pesticide effects on heat-clearing and anti-bacterial and anti-inflammatory, etc. Modern medical research has demonstrated that they also have profound effects in anti-HIV, anti-thrombus, liver protection and so on. Because they are difficult to be synthesized artificially, to increase the biosynthesis of andrographolide components in A. paniculata by cultivation regulation and breeding methods is of great significance to improve the quality of this medicinal material. To provide reference for related research in these fields, this paper reviewed the relationship between accumulation of andrographolide components and plant development, the effects of cultivation measures and environmental factors on the accumulation of andrographolide components, and the research advances in biosynthesis of andrographolide components and its molecular regulatory mechanism in the last decade worldwide. We also put forward three aspects which should be focused on in future studies aiming at enhancing the biosynthesis and accumulation of andrographolides components in A. paniculata:(1)To further identify the biosynthetic pathway of andrographolide components and the functions of key genes, and to elucidate the mechanism of andrographolides accumulation at molecular level;(2)To deeply study the laws of growth and development, yield and quality formation, and their interrelations in A. paniculata with the combination of molecular biological approaches and crop cultivation theories;(3)To reveal the signal regulation network in the biosynthesis of andrographolide components. |
| Key words: Andrographis paniculata, environmental factors, andrographolide, biosynthesis, phytohormone |
