金樱根化学成分的研究

丁 阳<sup>1; 2</sup>; 黄永林<sup>1</sup>; 刘金磊<sup>1</sup>; 王 磊<sup>1</sup>; 颜小捷<sup>1</sup>; 李典鹏<sup>1*</sup>

引用本文:	丁阳, 黄永林, 刘金磊, 王磊, 颜小捷, 李典鹏.金樱根化学成分的研究[J].广西植物,2017,37(2):255-259.[点击复制]
	DING Yang, HUANG Yong-Lin, LIU Jin-Lei, WANG Lei, YAN Xiao-Jie, LI Dian-Peng.Chemical constituents from the roots of Rosa laevigata[J].Guihaia,2017,37(2):255-259.[点击复制]

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金樱根化学成分的研究
丁阳^1,2, 黄永林¹, 刘金磊¹, 王磊¹, 颜小捷¹, 李典鹏^1*
1. 广西植物功能物质研究与利用重点实验室, 广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006;2. 广西中医药大学, 南宁 530001

摘要:

金樱根为三金片的主要成分,但目前对于金樱根的化学成分和药理作用研究甚少。为了阐明金樱根的物质基础和生物活性,该研究采用硅胶、Sephadex LH-20、MCI gel CHP 20P 等柱色谱以及HPLC半制备等方法,对金樱根(Rosa laevigata)的化学成分进行研究。结果表明:从中共分离得到9个化合物,经过波谱数据分析结合文献对照分别鉴定为儿茶素(1),表儿茶素(2),rosamultin(3),sericoside(4),2α,3α,19α,23-tetrahydroxy-urs-12-en-28-oic acid-3-O-β-D-glucopyranosyl ester(5),kaji-ichigoside F1(6),β-D-Glucopyranosyl 3β,19α-dihydroxy-2-oxo-urs-12-en-28-oate(7),胡萝卜苷(8),β-谷甾醇(9),其中化合物2、4、5、7为首次从该植物中分离得到。该研究结果为金樱根在功能医药领域的开发利用提供了理论依据。

关键词: 金樱根, 化学成分, 结构鉴定

DOI：10.11931/guihaia.gxzw201511021

分类号:Q946.8

文章编号:1000-3142(2017)02-0255-05

基金项目:广西壮族自治区“八桂学者”专项 [Supported by the Bagui Scholar Program of Guangxi]。

Chemical constituents from the roots of Rosa laevigata

DING Yang^1,2, HUANG Yong-Lin¹, LIU Jin-Lei¹, WANG Lei¹, YAN Xiao-Jie¹, LI Dian-Peng^1*

1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guangxi Institute of Botany, Guilin 541006, Guangxi, China;2. Guangxi University of Chinese Medicine, Nanning 530001, China

Abstract:

The roots of Rosa laevigata were the main ingredients of the Sanjin tablet, at present, the studies on the chemical constituents and pharmacological of the R. laevigata were relatively insufficient. In order to elucidate the material basis and the activity of R. laevigata, the constituents of R. laevigata were isolated by silica gel, Sephadex LH-20, MCI gel CHP 20P column chromatography and semi-preparative HPLC. Their structures were elucidated by anlalyzing their spectral data and comparing with the previously reported literatures. Nine compounds:(+)-catechin(1),(-)-epicatechin(2), rosamultin(3), sericoside(4), 2α, 3α, 19α, 23-tetrahydroxy-urs-12-en-28-oic acid-3-O-β-D-glucopyranosyl ester(5), kaji-ichigoside F1(6), β-D-Glucopyranosy 3β,19α-dihydroxy-2-oxo-urs-12-en-28-oate(7), daucosterol(8), β-sitosterol(9)were obtained. Compounds(2),(4),(5)and(7)were reported from the plant for the first time. The results provide scientific information for exploitation and medicine utilization of R. laevigata.

Key words: roots of Rosa laevigata, chemical constituents, structure identification