| 引用本文: | 易湘茜, 高程海, 何碧娟, 陈 波.红树植物木榄胚轴中苯丙素类化学成分研究[J].广西植物,2013,(2):191-194.[点击复制] |
| YI Xiang-Xi, GAO Cheng-Hai, HE Bi-Juan, CHEN Bo.Study on phenylpropanoids from hypocotyls of the mangrove plant Bruguiera gymnorrhiza[J].Guihaia,2013,(2):191-194.[点击复制] |
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| 摘要: |
| 从木榄胚轴中分离出7个苯丙素类化合物,运用波谱学确定了化合物结构,分别鉴定为莨菪亭(1)、Balanophonin(2)、开环异落叶松脂素(3)、臭失菜素A(4)、松脂素(5)、5'-甲氧基-(-)-松脂素(6)、Lyoniresinol-3α-O-β-D-glucopyranosides(7)。化合物1,3,7对肿瘤细胞株A549显示出弱抑制活性,IC50值分别为290.2、323.0、209.3 μg/mL。除化合物3和5以外,其他化合物均首次从该植物中分离得到。 |
| 关键词: 木榄 苯丙素 抗肿瘤 |
| DOI：10.3969/j.issn.1000-3142.2013.02.010 |
| 分类号:R914.4 |
| 基金项目: |
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| Study on phenylpropanoids from hypocotyls of the mangrove plant Bruguiera gymnorrhiza |
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YI Xiang-Xi1, GAO Cheng-Hai2*, HE Bi-Juan2, CHEN Bo2
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1.Guangxi University of Chinese Medicine, Nanning 530001, China;2.Guangxi
Academy of Sciences, Nanning 530007, China
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| Abstract: |
| Seven phenylpropanoids were isolated from the hypocotyls of Bruguiera gymnorrhiza and purified by repeated column chromatography on silica,Sephadex LH-20 gel,and HPLC and structurally identified by spectral analysis. The compounds were identified as Scopoletin(1),Balanophonin(2),Secoisolariciresinol(3),Cleomiscosin A(4),Pinoresinol(5),Medioresinol(6),and Lyoniresinol-3α-O-β-D-glucopyranosides(7). Anti-tumors activity bioassay indicated that compounds 1,3 and 7 had weak cytotoxicity toward human cancer cell lines A549 with IC50 of 290.2,323.0,and 209.3 μg/mL,respectively. All compounds were isolated from this plant for the first time except 3 and 5. |
| Key words: Bruguiera gymnorrhiza phenylpropanoids anti-tumors |
