石山巴豆枝叶的化学成分研究

夏梦雯<sup>1; 2</sup>; 宁德生<sup>1</sup>; 黄思思<sup>1</sup>; 程 玲<sup>1; 2</sup>; 吕仕洪<sup>1</sup>; 罗 蕾<sup>2</sup>; 潘争红<sup>1*</sup>

引用本文:	夏梦雯, 宁德生, 黄思思, 程玲, 吕仕洪,罗蕾, 潘争红.石山巴豆枝叶的化学成分研究[J].广西植物,2016,36(10):1186-1191.[点击复制]
	XIA Meng-Wen, NING De-Sheng, HUANG Si-Si, CHENG Ling, LV Shi-Hong, LUO Lei, PAN Zheng-Hong.Chemical constituents from the branches and leaves of Croton euryphyllus[J].Guihaia,2016,36(10):1186-1191.[点击复制]

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石山巴豆枝叶的化学成分研究
夏梦雯^{1, 2}, 宁德生¹, 黄思思¹, 程玲^{1, 2}, 吕仕洪¹,罗蕾², 潘争红^1*
1. 广西植物功能物质研究与利用重点实验室, 广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006;2. 云南师范大学化学化工学院, 昆明 650500

摘要:

石山巴豆(Croton euryphyllus)为大戟科(Euphorbiaceae)巴豆属(Croton)植物,主要分布于西南各省的岩溶石山地区,民间用于杀虫和治疗跌打损伤。为了阐明其化学物质基础,该研究采用硅胶柱层析、Sephadex LH-20、HPLC等方法对石山巴豆枝叶醇提物进行分离纯化。结果表明:共分离得到16个化合物,分别鉴定为异毛叶巴豆萜(1), jatrophoidin(2), 山藿香定(3), 异山藿香素(4), 山藿香素(5), 赖百当-13-烯-8,15-二醇(6), 7-酮基-β-谷甾醇(7),(22E)-5α,8β-表二氧麦角甾-6,22-二烯-3β-醇(8), 豆甾烷-4-烯-6β-醇-3-酮(9), 齐墩果烷-12-烯-2α,3β-二醇(10), 东莨菪内酯(11), 催吐萝芙木醇(12), lyratol F(13), 罗布麻酚A(14), 芹菜素(15), 金色酰胺醇酯(16)。所有化合物均为首次从该植物中分离得到,其中化合物8-16为首次从巴豆属中发现。

关键词: 石山巴豆, 化学成分, 二萜, 甾醇, 结构鉴定

DOI：10.11931/guihaia.gxzw201509026

分类号:

文章编号:1000-3142(2016)10-1186-06

基金项目:国家自然科学基金(21102023); 广西自然科学基金(2011GXNSFB018022); 中国科学院“西部之光”人才培养计划项目(2012)[Supported by the National Natural Science Foundation of China(21102023); the Natural Science Foundation of Guangxi(2011GXNSFB018022); the West Light Foundation of the Chinese Academy of Sciences(2012)]。

Chemical constituents from the branches and leaves of Croton euryphyllus

XIA Meng-Wen^1,2, NING De-Sheng¹, HUANG Si-Si¹, CHENG Ling^1,2, LV Shi-Hong¹, LUO Lei², PAN Zheng-Hong^1*

1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, Guangxi, China;2. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China

Abstract:

Croton euryphyllus(Euphorbiaceae)is mainly distributed in the karst region of Southwest China and has been used as a folk medicine to cure traumatic injury and kill insects. In order to clarify the chemical constituents of C. euryphyllus, the ethanol extract was separated by the chromatography(silica gel, Sephadex LH-20 and HPLC)and sixteen compounds were isolated. Their structures were elucidated as: isocrotocaudin(1), jatrophoidin(2), teucvidin(3), isoteucvin(4), teucvin(5), labd-13E-ene-8β,15-diol(6), 7-oxo-β-sitosterol(7),(22E)-5α, 8β-epidioxyergosta-6, 22-dien-3β-ol(8), stigmast-4-en-6β-ol-3-one(9), olean-12-en-2α,3β-diol(10), scopoletin(11), vomifoliol(12), lyratol F(13), apocynol A(14), apigenin(15), aurantiamide acetate(16). All compounds were firstly isolated from this plant, and compounds 8-16 were isolated from the genus Croton for the first time.

Key words: Croton euryphyllus, chemical constituents, diterpenoid, sterol, structure identification