| 引用本文: | 曹 玫, 贾睿琳, 江 南, 陶 翠, 魏 琴, 殷中琼.油樟叶挥发油的镇痛活性研究[J].广西植物,2013,(4):552-555.[点击复制] |
| CAO Mei, JIA Rui-Lin, JIANG Nan, TAO Cui,
WEI Qin, YIN Zhong-Qiong.Analgesic effects of essential oils purified fromCinnamomum longepaniculatum[J].Guihaia,2013,(4):552-555.[点击复制] |
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| 油樟叶挥发油的镇痛活性研究 |
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曹 玫1, 贾睿琳2, 江 南1, 陶 翠2, 魏 琴3, 殷中琼2
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1. 四川省医学科学院/四川省人民医院 中心实验室, 成都 610072;2. 四川农业大学
动物医学院, 四川 雅安 625014;3. 宜宾学院, 四川 宜宾 644000
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| 摘要: |
| 采用水蒸汽蒸馏法提取四川宜宾产油樟叶中挥发油,气相色谱-质谱联用仪鉴定油樟叶挥发油的主要化学成分,然后根据电热板和醋酸扭体实验研究不同剂量的油樟叶挥发油对小鼠疼痛阈值的影响。GC-MS结果显示,油樟叶挥发油主要含1,8-桉叶油素、α-萜品醇和香桧烯等26个主要化学成分,其中1,8-桉叶油素含量占58.55%。油樟叶挥发油中、低剂量组可延长小鼠对热致痛的痛阈时间,高、中剂量组可显著减少小鼠醋酸致痛扭体次数,镇痛百分率分别为74.69%和73.11%,与对照组呈极显著差异。 |
| 关键词: 挥发油 镇痛 电热板 醋酸扭体 |
| DOI：10.3969/j.issn.1000-3142.2013.04.022 |
| 分类号:Q949.95 |
| 基金项目: |
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| Analgesic effects of essential oils purified fromCinnamomum longepaniculatum |
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CAO Mei1, JIA Rui-Lin2, JIANG Nan1, TAO Cui2,
WEI Qin3, YIN Zhong-Qiong2*
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1. Central Laboratory, Sichuan Academy of Medical Sciences &2.Sichuan Provincial People's Hospital,
Chengdu 610072, China;3.2. College of Veterinary Medicine, Sichuan Agricultural University,
Ya'an 625014, China;4.3. Yibin University, Yibin 644000, China
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| Abstract: |
| The compositions of essential oils were analyzed by gas chromatography-mass spectrometer, in order to study analgesic effects of essential oils purified from Cinnamomum longepaniculatum. Tolerance of hot plate and test of body wrest were used to study the analgesic effect at different dosages of essential oils. The data showed that 26 main compounds had been identified which mainly included 1,8-cineole, abietinol, sabinene and so on. The essential oils significantly increased the threshold value of pain. The number of body wrest significantly decreased, which were caused by glacial acetic acid. The analgesia percentages in high and medium groups were 74.69% and 73.11%, respectively, which were significantly different with the negative control. It can be seen that the essential oils from C. longepaniculatum have analgesic effects. |
| Key words: essential oils analgesia hot plate acetic acid writhing |
