【专题：红豆属植物多样性保育研究】花榈木化学成分、药理作用研究进展及其质量标志物预测

Research progress on chemical composition and pharmacological effects of Ormosia henryi and predictive analysis of its quality markers

关键词:  花榈木，化学成分，药理活性，网络药理学，质量标志物

Key words:  Ormosia henryi, chemical composition, pharmacological activity, network pharmacology, quality markers

摘要:

花榈木（Ormosia henryi）是我国一种重要的药用植物，常以根、茎、叶入药，具有祛风除湿、活血化瘀、解毒消肿等传统功效。该研究系统综述了花榈木的化学成分及药理活性研究进展，结果表明：（1）花榈木化学成分主要包括生物碱、黄酮、萜类化合物及挥发油等，具有抗氧化、抗炎、抗肿瘤、抑菌和调节抑郁等多种药理活性。（2）基于中药质量标志物（Q-Marker）的“五原则”，从植物亲缘性、化学成分专属性、传统药性与药效、成分可测性和网络药理学评价等方面预测其Q-Marker。（3）初步认定圣草酚、木犀草素、金合欢素、香叶木素、山奈酚、柚皮素等黄酮类化合物可作为花榈木的潜在Q-Marker。该研究结果为完善花榈木质量评价体系提供了理论依据，为其药用价值开发和机制研究奠定了基础。

Abstract:

Ormosia henryi is a pharmacologically important plant in China, whose roots, stems, and leaves have long been used in traditional medicine for dispelling wind-dampness, promoting blood circulation, resolving stasis, detoxification, and alleviating edema. In this review, we synthesize current knowledge on the chemical constituents and pharmacological properties of O. henryi. The results were as follows: (1) Phytochemical studies have revealed that this species contains diverse classes of secondary metabolites—including alkaloids, flavonoids, terpenoids, and volatile oils — that contribute to a wide range of pharmacological activities such as antioxidant, anti-inflammatory, antitumor, antimicrobial, and antidepressant effects. (2) Guided by the five core principles of Quality Markers (Q-Markers) in traditional Chinese medicine, we identify candidate Q-Markers through an integrated framework that combines phylogenetic relationships, chemical specificity, traditional efficacy, quantifiable chemical indices, and network pharmacology. (3) Based on this analysis, key flavonoids — including eriodictyol, luteolin, acacetin, diosmetin, kaempferol, and naringenin — are proposed as potential Q-Markers. These findings provide a theoretical basis for establishing quality assessment protocols and offer new directions for exploring the medicinal value and underlying mechanisms of O. henryi.