| 摘要: |
| 采用75%乙醇萃取锈毛草莓及积雪草,制备成合剂,通过STZ诱导建立糖尿病小鼠模型,随机分为模型组、低剂量组及高剂量组,分别以蒸馏水、4及8 g·kg-1锈毛草莓积雪草合剂灌胃,1次·d-1,持续4周,另设正常组作为对照。探究绣毛草莓积雪草合剂对糖尿病小鼠的降血糖效果及作用机制。结果表明:(1)不同剂量的锈毛草莓积雪草合剂均能显著降低糖尿小鼠血糖值,提高糖耐量并减轻其多食、多饮、多尿的症状。(2)低剂量组小鼠血清TC、TG含量较模型组有显著提高(P<0.01或P<0.05),肝脏SOD、CAT活性显著提高(P<0.05),MDA含量明显降低。(3)低剂量黄毛草莓积雪草合剂效果优于二甲双胍,毒性实验显示锈毛草莓积雪草合剂实属无毒。该研究结果表明锈毛草莓积雪草合剂具有降血糖作用,同时能够降低糖尿病小鼠的血脂水平,其作用机制可能与提高肝脏抗氧化能力有关。 |
| 关键词: 锈毛草莓, STZ, 糖尿病, 降血糖, 抗氧化 |
| DOI：10.11931/guihaia.gxzw201704020 |
| 分类号:Q946.3 |
| 文章编号:1000-3142(2018)04-0451-06 |
| Fund project:上海市科委科研基金(16DZ2348900); 国家大学生创新项目(201610269091)[Supported by Science and Technology Foundation of Shanghai(16DZ2348900); National Training Programs of Innovation and Entrepreneurship for Undergraduates(201610269091)]。 |
|
| Antidiabetic effects of Fragaria nilgerrensis and Centella asiatica compound on STZ-induced diabetic mice |
|
GAO Liangcai*, WANG Xinyi, LU Shiyun, ZHOU Mengxuan, CHEN Qin, LIN Qingnan
|
|
Department of Biology Science, East China Normal University, Shanghai 200241, China
|
| Abstract: |
| We extracted medicine compound(FN-MC)by 75% ethanol. STZ-induced diabetic mice were randomly divided into model, low-dose and high-dose groups, respectively, and treated with distilled water and FN-MC at doses of 4 and 8 g·kg-1 for 4 weeks. Control group was treated with distilled water. The results showed that FN-MC could significantly lower the fasting blood glucose, reduced food and water intake, and improved the level of OGGT. Low-dose FN-MC could obviously increase the levels of TC and TG(P<0.01 or P<0.05), decrease the level of MDA, enhance the activities of SOD and CAT(P<0.05). Besides, Low-dose FN-MC was more effective than metformin. Toxicity test showed that FN-MC was non-toxic. In conclusion, FN-MC could decrease blood glucose in STZ-induced diabetic mice by mechanisms of enhancing the activity of antioxidant in liver. |
| Key words: Fragaria nilgerrensis, streptozotocin, diabetic, hypoglycemic, antioxidation |
