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| 大叶山楝根的化学成分及细胞毒活性研究 |
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李 薇1,2, 黄 淼1, 梅文莉1,2, 董文化1,2, 王 军1,2,
蔡彩虹1,2, 盖翠娟1,2, 戴好富1,2*
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1. 中国热带农业科学院热带生物技术研究所 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101;2. 海南省黎药资源天然产物研究与利用重点实验室, 海口 571101
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| 摘要: |
| 该研究从大叶山楝根95%乙醇提取物的乙酸乙酯萃取物中分离得到10个化合物,经波谱解析分别鉴定为schleicheol 2(1),β-扶桑甾醇(2),fregenedadiol(3),异巴西红厚壳素(4),丁香酯素(5),表丁香酯素(6),graminone A(7),sylvatesmin(8),Z-6-十九烯酸甲酯(9),棕榈酸(10)。其中,化合物1-4、化合物7-9为首次从山楝属植物中分离得到。细胞毒活性测试结果表明,化合物1和化合物2对人胃癌细胞SGC-7901生长具有一定的抑制活性。 |
| 关键词: 楝科, 大叶山楝, 化学成分, 细胞毒活性 |
| DOI：10.11931/guihaia.gxzw201706019 |
| 分类号:Q946.8 |
| 文章编号:1000-3142(2018)04-0457-06 |
| Fund project:国家公益性行业(农业)科研专项项目(201303117); 海南省重点研发计划项目(ZDYF2016140); 海南自然科学基金(2017CXTD020)[Supported by Special Fund for Agro-Scientific Research in the Public Interest(201303117); Special Fund for Key Research Program of Hainan Province(ZDYF2016140); Natural Science Foundation of Hainan(2017CXTD020)]。 |
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| Chemical constituents and cytotoxic activities ofroots from Aphanamixis grandifolia |
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LI Wei1,2, HUANG Miao1, MEI Wenli1,2, DONG Wenhua1,2, WANG Jun1,2,
CAI Caihong1,2, GAI Cuijuan1,2, DAI Haofu1,2*
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1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and
Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;2. Hainan Key Laboratory for
Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China
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| Abstract: |
| Aphanamixis grandifolia belongs to genus Aphanamixis of family Meliaceae. We made the experiment to clarify the constituents from the roots of A. grandifolia in this paper. The chemical constituents were isolated by silica gel, Sephadex LH-20 column chromatographic methods. The structures were identified by spectral analysis and comparing with the previously reported literatures. The results showed that ten compounds were isolated from the ethyl acetate of ethanol extract from A. grandifolia and identified respectively as schleicheol(1), β-rosasterol(2), fregenedadiol(3), isojacareubin(4), syringaresinol(5), episyringaresinol(6), graminone A(7), sylvatesmin(8), methyl-Z-6-nonadecenoate(9), ralmitic acid(10). The compounds 1-4, 7-9 were obtained from A. grandifolia for the first time. The results of cytotoxic activity showed that compounds 1 and 2 had certain inhibitory activity on the growth of human gastric cancer cell SGC-7901. |
| Key words: Meliaceae, Aphanamixis grandifolia, chemical constituents, cytotoxic activity |
