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葫芦叶马兜铃化学成分的分离
邱运平; 陈秀珍; 朱大元;
1.广西植物研究所;2.上海药物研究所
摘要:
葫芦叶马兜铃Aristolochia cucurbitoides C.F.Liang系马兜铃科马兜铃属植物,为宿根性多年生草质藤本,具圆形肉质根。分布于广西百色地区。民间用于止痛。其化学成分尚未见详细报导。我们对产自广西隆林县的样品,进行了化学成分的分离。现介绍其主要药用成分之一马兜铃酸的分离,葫芦叶马兜铃根中含粗马兜铃酸0.15%左右。经薄层、紫外光谱、红外光谱与已知马兜铃酸比较鉴定,其结果一致。为了进一步证明是马兜铃酸,经用锌粉醋酸在油浴中回流,得到黄绿色马兜铃内酰胺C18H11O4N与已知马兜铃内酰胺的薄层、紫外光谱、红外光谱对照基本一致。证明葫芦叶马兜铃根中分离出来的黄色微针状结晶是马兜铃酸(Aristolochic acid)。
关键词:  葫芦叶马兜铃  化学成分  马兜铃酸  马兜铃属  马兜铃科  Aristolochia  主要药用成分  红外光谱  草质藤本  紫外光谱  
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