| 摘要: |
| 从圆叶节节菜地上部分乙酸乙酯层中分离得到8个化合物,经波谱学方法分别鉴定为pomolic acid 3β-acetate(1),7-oxo-β-sitosterol(2),6β-hydroxystigmast-4-en-3-one(3),esculetin(4),phyllemblin(5),1,2-O-di-galloylglycerol(6),apigenin(7),quercetin(8),以上化合物均为首次从该植物中分离得到。化合物(6)在GK,SIRT1激动活性及DPPIV,11β-HSD抑制活性等抗糖尿病体外活性测试中均无明显的活性。 |
| 关键词: 圆叶节节菜 化学成分 葡萄糖激酶 二肽基肽酶IV 11β-羟基类固醇脱氢酶 糖尿病 |
| DOI：10.3969/j.issn.1000-3142.2013.06.027 |
| 分类号:R284.2 |
| Fund project: |
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| Chemical constituents of Rotala rotundifolia |
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TAN Qin-Gang1, LAI Chun-Hua1, WANG Heng-Shan2*
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1. Guilin Medical University, Guilin 541004, China;2. Guangxi Normal University, Guilin 541004, China
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| Abstract: |
| Eight compounds were isolated from the ethyl acetate extraction of the aerial parts of Rotala rotundifolia,which were identified as pomolic acid 3β-acetate(1),7-oxo-β-sitosterol(2),6β-hydroxystigmast-4-en-3-one(3),esculetin(4),phyllemblin(5),1,2-O-di-galloylglycerol(6),apigenin(7),and quercetin(8)by spectra analysis,and all of them were obtained from this species for the first time. Compound 6 showed no activity against glucokinase,SIRT1,DPPIV,11β-HSD in vitro anti-diabetes screening tests. |
| Key words: Rotala rotundifolia chemical constituents glucokinase DPPIV 11β-HSD diabetes |
