| 摘要: |
| 石山巴豆(Croton euryphyllus)为大戟科(Euphorbiaceae)巴豆属(Croton)植物,主要分布于西南各省的岩溶石山地区,民间用于杀虫和治疗跌打损伤。为了阐明其化学物质基础,该研究采用硅胶柱层析、Sephadex LH-20、HPLC等方法对石山巴豆枝叶醇提物进行分离纯化。结果表明:共分离得到16个化合物,分别鉴定为异毛叶巴豆萜(1), jatrophoidin(2), 山藿香定(3), 异山藿香素(4), 山藿香素(5), 赖百当-13-烯-8,15-二醇(6), 7-酮基-β-谷甾醇(7),(22E)-5α,8β-表二氧麦角甾-6,22-二烯-3β-醇(8), 豆甾烷-4-烯-6β-醇-3-酮(9), 齐墩果烷-12-烯-2α,3β-二醇(10), 东莨菪内酯(11), 催吐萝芙木醇(12), lyratol F(13), 罗布麻酚A(14), 芹菜素(15), 金色酰胺醇酯(16)。所有化合物均为首次从该植物中分离得到,其中化合物8-16为首次从巴豆属中发现。 |
| 关键词: 石山巴豆, 化学成分, 二萜, 甾醇, 结构鉴定 |
| DOI：10.11931/guihaia.gxzw201509026 |
| 分类号: |
| 文章编号:1000-3142(2016)10-1186-06 |
| Fund project:国家自然科学基金(21102023); 广西自然科学基金(2011GXNSFB018022); 中国科学院“西部之光”人才培养计划项目(2012)[Supported by the National Natural Science Foundation of China(21102023); the Natural Science Foundation of Guangxi(2011GXNSFB018022); the West Light Foundation of the Chinese Academy of Sciences(2012)]。 |
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| Chemical constituents from the branches and leaves of Croton euryphyllus |
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XIA Meng-Wen1,2, NING De-Sheng1, HUANG Si-Si1, CHENG Ling1,2,
LV Shi-Hong1, LUO Lei2, PAN Zheng-Hong1*
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1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences,
Guilin 541006, Guangxi, China;2. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
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| Abstract: |
| Croton euryphyllus(Euphorbiaceae)is mainly distributed in the karst region of Southwest China and has been used as a folk medicine to cure traumatic injury and kill insects. In order to clarify the chemical constituents of C. euryphyllus, the ethanol extract was separated by the chromatography(silica gel, Sephadex LH-20 and HPLC)and sixteen compounds were isolated. Their structures were elucidated as: isocrotocaudin(1), jatrophoidin(2), teucvidin(3), isoteucvin(4), teucvin(5), labd-13E-ene-8β,15-diol(6), 7-oxo-β-sitosterol(7),(22E)-5α, 8β-epidioxyergosta-6, 22-dien-3β-ol(8), stigmast-4-en-6β-ol-3-one(9), olean-12-en-2α,3β-diol(10), scopoletin(11), vomifoliol(12), lyratol F(13), apocynol A(14), apigenin(15), aurantiamide acetate(16). All compounds were firstly isolated from this plant, and compounds 8-16 were isolated from the genus Croton for the first time. |
| Key words: Croton euryphyllus, chemical constituents, diterpenoid, sterol, structure identification |
