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| 野艾蒿化学成分和药理作用研究进展 |
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陈 宁1,2, 王梓林1,2, 刘 冰1,2*, 芦瑞洋1,2, 孙小情1,2, 王贞妮1,2, 杨 燚1,2
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1. 哈尔滨商业大学药物工程技术研究中心, 哈尔滨 150076;2. 国家教育部抗肿瘤天然药物工程研究中心, 哈尔滨 150076
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| 摘要: |
| 野艾蒿(Artemisia lavandulifolia)为我国传统中药,属于菊科(Compositae)植物,广泛分布于我国东北、华北等地区,具有巨大的开发潜力和丰富的资源。近年来,从野艾蒿中成功分离出许多具有新颖结构和显著药理活性的化合物,相关研究取得了显著进展。该文对野艾蒿的主要化学成分、提取分离方法、结构鉴定技术以及药理作用等方面进行了综合归纳总结。野艾蒿主要化学成分包括79个萜类化合物和挥发油、17个黄酮类化合物、6个木脂素类化合物和2个咖啡酸类化合物,还富含微量元素、维生素和氨基酸。野艾蒿化学成分具有显著的抗肿瘤、抗炎、抗氧化、降血脂、抑菌和杀虫等药理作用,但相关机制仍需进一步阐明。在此基础上,该文侧重关注野艾蒿的化学成分和药理作用,以挖掘更多具有临床价值的成分和作用机制。此外,该文也指出了野艾蒿在药用价值和现有研究方面存在的不足之处,并提出了未来的研究方向和建议,以促进野艾蒿的合理药用开发和综合利用,为今后相关研究提供参考和指导。 |
| 关键词: 野艾蒿, 萜类, 挥发油, 抗肿瘤, 抗炎, 抗氧化, 降血脂, 抑菌 |
| DOI：10.11931/guihaia.gxzw202307029 |
| 分类号:Q946 |
| 文章编号:1000-3142(2024)07-1377-15 |
| Fund project:黑龙江省自然科学基金优秀青年项目(YQ2021H003); 黑龙江省博士后基金(LBH-Q20103); 黑龙江省普通本科高校青年创新人才培养计划项目。 |
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| Research progress on chemical components and pharmacological effects of Artemisia lavandulifolia |
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CHEN Ning1,2, WANG Zilin1,2, LIU Bing1,2*, LU Ruiyang1,2,
SUN Xiaoqing1,2, WANG Zhenni1,2, YANG Yi1,2
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1. Pharmaceutical Engineering Technology Research Center of Harbin University of Commerce, Harbin 150076, China;2. National Ministry of Education Antitumor Natural Drug Engineering Research Center, Harbin 150076, China
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| Abstract: |
| Artemisia lavandulifolia is a traditional Chinese medicine in China, belonging to the Compositae family. It is widely distributed in Northeast and North China, with enormous development potential and abundant resources. In recent years, many compounds with novel structures and significant pharmacological activities have been successfully isolated from A. lavandulifolia, and significant progress has been made in related research. This article comprehensively summarizes the main chemical components, extraction and separation methods, structural identification techniques, and pharmacological effects of A. lavandulifolia. The main chemical components of A. lavandulifolia include 79 terpenoids and volatile, 17 flavonoids, 6 lignans, and 2 caffeic acid compounds. In addition, it is also rich in trace elements, vitamins, and amino acids. The chemical components of A. lavandulifolia have significant pharmacological effects such as anti-tumor, anti-inflammatory, antioxidant, blood lipid-lowering, antibacterial, and insecticidal functions. However, the relevant mechanisms still need to be further elucidated. On this basis, the article focuses on the chemical components and pharmacological effects of A. lavandulifolia, in order to explore more clinically valuable components and mechanisms of action. In addition, the article also pointed out the shortcomings of A. lavandulifolia in terms of medicinal value and existing research, and it proposed future research directions and suggestions to promote the rational medicinal development and comprehensive utilization of A. lavandulifolia, providing the reference and guidance for related research in future. |
| Key words: Artemisia lavandulifolia, terpenoids, volatile oil, anti-tumor, anti-inflammatory, antioxidant, blood lipid-lowering, antibacterial |
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