星刺卫矛的化学成分研究

Chemical constituents of Euonymus actinocarpus

关键词:  卫矛属, 星刺卫矛, 化学成分, 三萜

Key words:  Euonymus, Euonymus actinocarpus, chemical constituents, triperpenoids

摘要:

为探究卫矛科卫矛属植物星刺卫矛(Euonymus actinocarpus)的化学成分,该文采用正相硅胶、Sephadex LH-20和半制备液相HPLC等色谱技术对其进行分离和纯化。结果表明:(1)从星刺卫矛地上部分95%乙醇提取物中分离得到10个化合物,根据其理化常数和波谱(ESI-MS、¹H-NMR、¹³C-NMR)数据鉴定化合物结构为羽扇豆醇(1),蒲公英萜醇(2),表木栓醇(3),槐二醇(4),蒲公英萜酮(5),高粱醇(6),羽扇豆醇乙酸酯(7),木栓酮(8),β-谷甾醇(9),胡萝卜苷(10)。(2)所有化合物均为首次从星刺卫矛中分离得到。(3)星刺卫矛地上部分主要含有三萜和甾体类成分,其中三萜类型以木栓烷型、齐墩果烷型和羽扇豆烷型骨架为主。该研究结果增加了对星刺卫矛物质基础的认识,为开发和利用卫矛属植物资源提供了一定的科学依据。

Abstract:

To investigate the chemical constituents of Euonymus actinocarpus in genus Euonymus of family Celastraceae, column chromatography on silica gel, Sephadex LH-20 and semi-preparative liquid chromatography were applied for the isolation and purification of the constituents. The structures were elucidated on the basis of spectral analysis and by comparison the data in literature. The results were as follows:(1)Ten compounds were isolated from the 95%EtOH extract of aerial part of E. actinocarpus, and their structures were identified as lupeol(1), taraxerol(2), epifriedelinol(3), sophoradiol(4), taraxerone(5), sorghumol(6), lupeol acetate(7), friedelin(8), β-sitosterol(9), daucosterol(10), respectively.(2)All isolated compounds 1-10 were reported from E. actinocarpus for the first time.(3)The aerial part of E. actinocarpus mainly contained triterpenoids and steroids, furthermore, the triterpenoids mainly involved pedunane, oleanane and lupanane type skeletons. The results increase the understanding of the material basis of E. actinocarpus, and provide a certain scientific basis for the development and utilization of Euonymus plant resources.