鹧鸪花中一个新的木脂素

A new lignan from Heynea trijuga

关键词:  鹧鸪花, 化学成分, 分离纯化, 结构鉴定, 8-O-4'-木脂素

Key words:  Heynea trijuga, chemical constituents, isolation and purification, structural identification, heynealigan A

摘要:

为明确鹧鸪花枝叶的化学物质基础,该研究采用硅胶柱色谱、MCI、C₁₈、Sephadex LH-20及制备HPLC等色谱技术对其进行分离和纯化,并通过理化性质和波谱数据鉴定化合物的结构。结果表明:(1)从鹧鸪花枝、叶的甲醇提取物中分离得到6个单体化合物,分别鉴定为新化合物8-O-4'-木脂素,即heynealigan A(1)、3β,21-dihydroxy-24-methylenecycloartane(2)、3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3)、16-dehydeoxy-23β-hydroxymeliasenin F(4)、ergost-5, 24(28)-diene-3β, 23S-diol(5)、7α-羟基谷甾醇(6)。(2)化合物1为新的木脂素,化合物2-4为三萜化合物,化合物5和化合物6为甾体化合物,化合物2-5为首次从该植物中分离得到。该研究结果为鹧鸪花的合理开发利用提供了科学依据。

Abstract:

In order to study the chemical constituents from the branches and leaves of Heynea trijuga, silica gel, MCI, C₁₈, Sephadex LH-20 and preparative HPLC were applied for the isolation and purification of the constituents. The structures were identified by physicochemical properties and spectrum data. The results were as follows:(1)Six compounds were obtained from methanol extracts of H. trijuga, their structures were identified as heynealigan A(1), 3β,21-dihydroxy-24-methylenecycloartane(2), 3-oxo-threo-23,24,25-trihydroxytirucall-7-ene(3), 16-dehydeoxy-23β-hydroxyliasenin F(4), ergost-5, 24(28)-diene-3β, 23S-diol(5), 7α-hydrositosteol(6).(2)Compound 1 was a new lignan, compounds 2-4 were triterpenoids, compounds 5 and 6 were steroids, and compounds 2-5 were isolated from this plant for the first time. This study provides scientific basis for the rational development and utilization of T. connaroides.