罗汉松内生真菌Pestalotiopsis heterocornis的代谢产物研究

鲍真真<sup>1</sup>; 吴 洁<sup>1*</sup>; 王奎武<sup>2</sup>; 吴 斌<sup>3</sup>; 钟 嫄<sup>1</sup>

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*罗汉松内生真菌Pestalotiopsis heterocornis的代谢产物研究*
鲍真真¹, 吴洁^1*, 王奎武², 吴斌³, 钟嫄¹
1. 江苏卫生健康职业学院药学院, 南京 211800;2. 浙江工商大学食品科学与生物技术学院, 杭州 310035;3. 浙江大学海洋学院, 浙江舟山 316021

摘要:

从罗汉松内生真菌Pestalotiopsis heterocornis 的发酵培养液中分离得到10个代谢产物,应用质谱、核磁共振等现代波谱学方法鉴定为 jesterone(1),hydroxy-jesterone(2),ambuic acid(3),6β-羟基-豆甾-4-烯-3-酮(4),(24S)-麦角甾-5-烯-3β, 7α-二醇(5),7, 22-二烯-3β, 5α, 7β-三羟基-麦角甾醇(6),麦角甾-7, 22-二烯-3-酮(7),(4E, 8E, 2S, 3R, 2'R)-N-2'-羟基棕榈酰-9-甲基-4, 8-sphingadienin(8),鲨肝醇(9),棕榈酸(10)。以上化合物均为首次从内生真菌P. heterocornis 的代谢产物中分离得到,化合物 4,6,7 为首次从拟盘多毛孢属真菌代谢产物中分离得到。

关键词: 内生真菌, Pestalotiopsis heterocornis, 代谢产物

DOI：10.11931/guihaia.gxzw201812030

分类号:Q946

文章编号:1000-3142(2019)11-1568-05

Fund project:国家自然科学基金面上项目(81573306); 江苏省“六大人才高峰”项目(2015-XCL-036); 江苏省青蓝工程优秀教学团队; 江苏省高等学校自然科学研究项目(19KJD430005); 江苏省高等职业教育青年教师企业实践(2019QYSJPX171)[Supported by the National Natural Science Foundation of China(81573306); Six Talent Peaks Program in Jiangsu Province(2015-XCL-036); Qinglan Program of Excellent Teaching Team in Jiangsu Province; The Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJD430005); Practical Training Program for Young Teachers in Higher Vocational Colleges in Jiangsu Province(2019QYSJPX171)]。

Metabolites of endophytic fungus Pestalotiopsis heterocornis isolated from Podocarpus macrophyllus

BAO Zhenzhen¹, WU Jie^1*, WANG Kuiwu², WU Bin³, ZHONG Yuan¹

1. School of Pharmacy, Jiangsu Health Vocational College, Nanjing 211800, China;2. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China;3. Ocean College, Zhejiang University, Zhoushan 530005, Zhejiang, China

Abstract:

Ten compounds were isolated and identified from endophytic fungi Pestalotiopsis heterocornis, isolated from Podocarpus macrophyllus, which collected in Hangzhou, China. Their structures were elucidated on the basis of spectroscopic data as jesterone(1), hydroxy-jesterone(2), ambuic acid(3), 6β-Hydroxystigmast-4-en-3-one(4),(24S)-ergosta-5-en-3β, 7α-diol(5), ergosta-7, 22- dien-3β, 5α, 7β-triol(6),ergosta-7, 22-dien-3-one (7),(4E, 8E, 2S, 3R, 2'R)-N-2'-hydroxyhexadecanoyl-9-methyl-4, 8-sphingadienin(8), batyl alcohol(9), palmitic acid(10). All compounds were isolated from P. heterocornis for the first time, and compounds 4, 6, 7 were obtained for the first time from Pestalotiopsis spp.

Key words: endophytic fungi, Pestalotiopsis heterocornis, metabolites