| 摘要: |
| 桂枝是临床常用中药,本课题组前期发现桂枝乙醇提取物具有抑制程序性细胞坏死的生理活性。为进一步阐明桂枝的化学成分和更好地开发利用桂枝药用资源,该文采用大孔吸附树脂、硅胶柱色谱、Sephadex LH-20柱层析、制备型高效液相色谱等多种方法对桂枝75%乙醇提取物进行了研究。此次报道从中得到的13个单体化合物,它们的结构经波谱数据分析及文献对照鉴定为脱落酸(1)、蚱蜢酮(2)、2,3-二羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮(3)、赤型-1,2,3-三羟基苯丙烷(4)、1-苯基-1,3-丙二醇(5)、香豆素(6)、肉桂酸(7)、对羟基肉桂酸(8)、邻羟基肉桂酸(9)、邻甲氧基肉桂酸(10)、肉桂醛(11)、阿魏酸(12)、咖啡酸乙酯(13)。其中1-5、12和13为首次从桂枝中分离得到。 |
| 关键词: 桂枝, 75%乙醇提取物, 化学成分, 分离, 鉴定 |
| DOI：10.11931/guihaia.gxzw202009032 |
| 分类号:Q946 |
| 文章编号:1000-3142(2022)05-0860-06 |
| Fund project:国家自然科学基金(81760706); 江西省卫生与健康委员会科技计划项目(20203769); 江西省中医药大学中药学一流学科专项科研基金项目(JXSYLXK-ZHYAO022,JXSYLXK-ZHYAO112)[Supported by National Natural Science Foundation of China(81760706); Science and Technology Plan Project of Jiangxi Provincial Health and Health Commission(20203769); Chinese Medicine First-class Discipline Special Science and Technology Project Founded by Jiangxi University of Traditional Chinese Medicine(JXSYLXK-ZHYAO022,JXSYLXK-ZHYAO112)]。 |
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| Chemical constituents of Cinnamomi Ramulus |
|
JIN Yongliang1, CHEN Guanyi2, LIU Wenqin1, WAN Pingnan1,
CHEN Zhongwen1, LIU Hua1*
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1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. Science and
Technology College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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| Abstract: |
| Cinnamomi Ramulus is a traditional Chinese medicine commonly used in clinic. The ethanol extracts of Cinnamomi Ramulus has the physiological activity to inhibit necroptosis in the previous studies. In order to clarify the chemical constituents of this plant and to provide scientific basis for the rational development and sustainable utillization of the plant resources, the 75% ethanol extracts of Cinnamomi Ramulus were isolated and purified by chromatographic methods such as macroporous adsorption resin, silica gel, Sephadex LH-20 and preparative HPLC, and 13 compounds were obtained. Their structures were identified by physicochemical properties and spectral data analyses as abscisic acid(1), grasshopper ketone(2), 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone(3), erythro-type-1,2,3-trihydr-oxyphenylpropane(4), 1-phenyl-1,3-propanediol(5), coumarin(6), cinnamic acid(7), p-hydroxycinnamic acid(8), o-hydroxycinnamic acid(9), o-methoxycinnamic acid(10), cinnamaldehyde(11), ferulic acid(12), ethyl caffeic acid(13). Among them, 1-5, 12 and 13 were isolated from the plant for the first time. |
| Key words: Cinnamomi Ramulus, 75% ethanol extracts, chemical constituents, isolation, identification |
