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| 钩毛茜草蒽醌类化学成分的研究 |
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李 银1,3, 黄鸿运1,3, 黄 勇2, 何燕玲1, 3, 汪 洋1, 3, 李勇军1*
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1. 贵州医科大学 民族药与中药开发应用教育部工程研究中心/省部共建药用植物功效与利用国家重点实验室, 贵阳 550004;2. 贵州医科大学 贵州省药物制剂重点实验室, 贵阳 550004;3. 贵州医科大学 药学院, 贵阳 550004
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| 摘要: |
| 为研究我国特有植物钩毛茜草(Rubia oncotricha)的化学成分,该文将钩毛茜草70%乙醇提取物采用硅胶、凝胶柱色谱等进行分离纯化,并对所得化合物进行结构鉴定。结果表明:从钩毛茜草中共分离了15个蒽醌类化合物,分别是2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside(1)、2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-α-rhamnosyl(1→2)-β-glucoside(2)、2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(3'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside(3)、2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-β-glucoside(4)、1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside(5)、2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside(6)、大黄素甲醚-8-O-β-D-葡萄糖苷(7)、大黄素-8-O-β-D-葡萄糖苷(8)、digiferruginol-11-O-β-gentiobioside(9)、2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(10)、6-hydroxyrubiadin(11)、1,2-二羟基蒽醌(12)、大黄酚(13)、6-hydroxyxanthopurpurin(14)、1,3-二羟基蒽醌(15)。化合物7、8、14为首次从茜草属植物中分离得到,化合物1-6、9、10、12、13为首次从该药材中分离得到。 |
| 关键词: 钩毛茜草, 化学成分, 蒽醌, 分离纯化, 结构鉴定 |
| DOI：10.11931/guihaia.gxzw202009054 |
| 分类号:Q946; R284.1 |
| 文章编号:1000-3142(2022)05-0866-08 |
| Fund project:国家自然科学基金(U1812403); 贵州省大学生创新训练项目(2018520363); 中央引导地方科技专项项目(黔科中引地 [2018]4006); 贵州省科学技术厅人才团队项目(黔科合平台人才 [2016]5677)[Supported by National Natural Science Foundation of China(U1812403); Guizhou Province University Student Innovation Training Project(2018520363); Central Government Guides Local Science and Technology Special Project([2018]4006); Talent Team Project of Guizhou Provincial Department of Science and Technology([2016]5677)]。 |
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| Chemical constituents of anthraquinone from Rubia oncotricha |
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LI Yin1, 3, HUANG Hongyun1, 3, HUANG Yong2, HE Yanling1, 3,
WANG Yang1, 3, LI Yongjun1*
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1. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM/State Key Laboratory of Functions and
Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China;2. Guizhou Provincial Key Laboratory of Pharmaceutics,
Guizhou Medical University, Guiyang 550004, China;3. School of Pharmacy, Guizhou Medical University, Guiyang 550004, China
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| Abstract: |
| To study the chemical constituents of China endemic plant Rubia oncotricha, the compounds were isolated with 70% ethyl alcohol and purified by silica gel, gel column chromatography, and their structures were elucidated by modern spectroscopic techniques. The results showed that fifteen anthraquinone compounds were isolated and identified from R. oncotricha, they were 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside(1), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-α-rhamnosyl(1→2)-β-glucoside(2), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(3'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside(3), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-β-glucoside(4), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside(5), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-glucopyranoside(6), physcion-8-O-β-D-glucopyranoside(7), emodin-8-O-β-D-glucopyranoside(8), digiferruginol-11-O-β-gentiobioside(9), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(10), 6-hydroxyrubiadin(11), 1,2-dihydroxyanthraquinone(12), chrysophanol(13), 6-hydroxyxanthopurpurin(14), 1,3-dihydroxyanthraquinone(15). Compounds 7, 8 and 14 are isolated from the genus of Rubia for the first time, compound 1-6, 9, 10, 12, 13 are isolated from R. oncotricha for the first time. |
| Key words: Rubia oncotricha, chemical constituents, anthraquinone, isolation and purification, structure identification |
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